任无畏，上海科技大学信息学院助理教授/研究员/博导，研究兴趣包括光学成像、图像重建，以及荧光手术导航和光学脑机接口等应用。曾就读于浙江大学、瑞典皇家理工学院和瑞士苏黎世联邦理工学院，并分别获得学士、硕士和博士学位；后在瑞士苏黎世大学医学院及药学院完成博士后研究。近五年来，以通信作者身份在 Nature Communications、Laser & Photonics Reviews、IEEE TMI、IEEE TBME、Optics Express、Biomedical Optics Express、Physics in Medicine & Biology 等期刊发表学术成果。自主研发的光学成像原型机曾获 Venture Kick 等欧洲创业奖项，并参展德国汉诺威工业展。申报中国专利 8 项、国际专利（PCT）1 项。主持瑞士 BRIDGE 转化基金、国家自然科学基金（青年、面上）、上海市关键技术研发计划及迈瑞医疗横向课题等项目，入选上海市“青年东方学者”和上海市领军计划。长期担任 Optica、IEEE 等学协会旗下期刊审稿人，并担任《Neuroelectronics》《中国激光》等期刊青年编委，SPIE Photonics West、欧洲分子成像年会等国际会议分会主席，以及科技部国家重点研发计划、工信部相关项目会评专家。

【学生培养】本实验室欢迎对成像科学有浓厚兴趣的同学加入！专业背景包括计算机、电子、应用数学和光学工程等。毕业学生去向包括海外深造（新加坡南洋理工大学、英国伯明翰大学全额奖学金博士）、国内知名医疗器械公司（如联影）。

定量生物光子学与光学成像

技术方向一：病态光学逆问题的物理约束重建

代表性论文（技术方向一）

1. Zhao S, et al., Ren W*. μNeuFMT: Background-Optical-Property-Adaptive Fluorescence Molecular Tomography via Implicit Neural Representation. IEEE Transactions on Medical Imaging, 2026, Early Access.

2. Zhang J, et al., Ren W*. High-Fidelity Solution Decomposition Fluorescence Tomography in the Presence of Background Interference. Laser & Photonics Reviews, 20(2), 2026, e01013. [Cover]

3. Shen S, et al., Ren W*. High Resolution Diffuse Optical Tomography via Neural Fields. IEEE Transactions on Computational Imaging, 11, 2025, 955–966.

4. Ren W, et al. Smart Toolkit for Fluorescence Tomography: Simulation, Reconstruction, and Validation. IEEE Transactions on Biomedical Engineering, 67, 2020, 16–26.

技术方向二：面向定量成像的结构光照明与时间分辨探测

代表性论文（技术方向二）

1. Li L, et al., Ren W*. Accelerated SPAD-based diffuse optical tomography with data-driven view optimization. Journal of Biophotonics, 19(6), 2026, e70289.

2. Zhao W, et al., Ren W*. Systematic validation of time-resolved diffuse optical simulators via non-contact SPAD-based measurements. Physics in Medicine & Biology, 71(12), 2026, 125041.

3. Gao S, et al., Ren W*. Multifunctional Optical Tomography System with High-Fidelity Surface Extraction Based on a Single Programmable Scanner and Unified Pinhole Modeling. IEEE Transactions on Biomedical Engineering, 71(4), 2024, 1391–1403.

4. Hu Y, et al., Ren W*. Simultaneous reconstruction of 3D fluorescence distribution and object surface using structured light illumination and dual-camera detection. Optics Express, 32(9), 2024.

5. Ren W*, et al. Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography. Optics Express, 28, 2020, 9860–9874.

技术方向三：强硬件约束下的高保真微型显微成像

代表性论文（技术方向三）

1. Gu L, et al., Ren W*. High-fidelity miniature fluorescence microscopy using Zernike-based point-spread-function modeling and hardware-assisted calibration. Laser & Photonics Reviews, 20(18), 2026, e02485. [Cover]

2. Xu J, et al., Ren W*. Compact dual-wavelength miniature fluorescence microscope based on spectral multiplexing. Optics Letters, 51(19), 2026, 5577–5580.

3. Zhu X, et al., Ren W*. MiniMounter: a low-cost miniaturized microscopy development toolkit for image quality control and enhancement. Journal of Biophotonics, 17(2), 2024, e202300214.

应用方向：多尺度神经成像与临床转化

代表性论文（应用方向）

1. Wu Y, et al., Ren W*. Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo. Nature Communications, 15, 2024, 2341. [ESI Highly Cited Paper]

2. Li F, et al., Ren W*. Lanthanide lifetime nanothermometer boosted by energy migration network for high-speed in vivo temperature imaging. Nature Communications, 2026, accepted in principle.

3. Ren W*, et al. Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography. Biomedical Optics Express, 14, 2023, 1192–1204.

4. Ren W*, et al. Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography. Biomedical Optics Express, 13, 2022, 3809–3822.

5. Chen Z, et al., Ren W. Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging. Light: Science & Applications, 11, 2022, 332.

数字信号处理｜ShanghaiTech-EE152｜2021–2026 春季

数字图像处理｜ShanghaiTech-CS270｜2021–2023 秋季

多模态脑机接口｜ShanghaiTech-SI361｜2021–2024 春季

新课程｜生物医学光子学及成像｜ShanghaiTech-EE280｜2024–2026 秋季

课程安排：涵盖基础理论、核心成像技术、非成像光学技术与多项课程实践。

课程实践：组织学生参访实验室，并在课堂开展成像系统演示与动手实践。

信息学院新闻链接：

https://sist.shanghaitech.edu.cn/2025/1110/c2858a1116737/page.htm

专家讲座：邀请 Vasilis Ntziachristos 教授（慕尼黑工业大学）等国际生物光子学专家授课。

系列专家讲座：围绕 EE280 课程主题，邀请多位国内外学者介绍生物光子学前沿方向。

期刊杂志

1. Zhao S, Zhang J, Wu Y, Li L, Shen S, Zhu X, Zheng G*, Jiang J, Ren W* (2026). μNeuFMT: Background-Optical-Property-Adaptive Fluorescence Molecular Tomography via Implicit Neural Representation. IEEE Transactions on Medical Imaging. Early Access.

2. Li F, Wu Y, Zhao R, Zhang M, Wang H, Zhao W, Li X, Wu Z, Gu L, Li F*, Ren W*, Zhu X* (2026). Lanthanide lifetime nanothermometer boosted by energy migration network for high-speed in vivo temperature imaging. Nature Communications. Accepted in principle.

3. Gu L, Liu Y, Zhu X, Li R, Zhou N, Dong J*, Ren W* (2026). High-fidelity miniature fluorescence microscopy using Zernike-based point-spread-function modeling and hardware-assisted calibration. Laser & Photonics Reviews, 20(18), e02485. [Cover]

4. Zhang J, Li L, Hu Q, Zhang J, Wu Y, Gu L, Li J, Li F, Zhu X*, Jiang J*, Ren W* (2026). High-Fidelity Solution Decomposition Fluorescence Tomography in the Presence of Background Interference. Laser & Photonics Reviews, 20(2), e01013. [Cover]

5. Li L, Kuang K, Lin Y, Zhang J, Chen B, Jiang J, Bruschini C, Charbon E*, Ren W* (2026). Accelerated SPAD-based diffuse optical tomography with data-driven view optimization. Journal of Biophotonics, 19(6), e70289.

6. Zhao W, Li L, Kuang K, Lin Y, Bruschini C, Cao J, Li T, Charbon E*, Ren W* (2026). Systematic validation of time-resolved diffuse optical simulators via non-contact SPAD-based measurements. Physics in Medicine & Biology, 71(12), 125041.

7. Xu J, Zhu X, Gu L, Li Y, Feng J, Ren W* (2026). Compact dual-wavelength miniature fluorescence microscope based on spectral multiplexing. Optics Letters, 51(19), 5577–5580.

8. Wu Q, Guo X, Chen L, Liu Y, Ren W, Zhang Y, Zhou SK, Yu J, Zhang Y (2026). Solving energy-independent density for CT metal artifact reduction via neural representation. IEEE Transactions on Radiation and Plasma Medical Sciences.

9. Landman MS*, Jiang J*, Zhang J, Ren W (2025). Augmented Flexible Krylov Subspace methods with applications to Bayesian inverse problems. Linear Algebra and its Applications, 721, 172–201.

10. Shen S, Li L, Gao S, Wang Y, Gu L, Li S, Zhu X, Jiang J*, Yu J*, Ren W* (2025). High Resolution Diffuse Optical Tomography via Neural Fields. IEEE Transactions on Computational Imaging, 11, 955–966.

11. Wang J, Pan B, Wang Z, Zhang J, Zhou Z, Yao L, Wu Y, Ren W, Wang J, Ji H, Yu J*, Chen B* (2024). Single-pixel p-graded-n junction spectrometers. Nature Communications, 15, 1773.

12. Wu Y, Li F, Wu Y, Wang H, Gu L, Zhang J, Qi Y, Meng L, Kong N, Chai Y, Hu Q, Xing Z, Ren W*, Li F*, Zhu X* (2024). Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo. Nature Communications, 15, 2341. [ESI Highly Cited Paper]

13. Zhang J, Wang Z, Cao T, Cao G*, Ren W*, Jiang J* (2024). Robust residual-guided iterative reconstruction for sparse-view CT in small animal imaging. Physics in Medicine & Biology, 69(10), 105010.

14. Hu Y, Wu Y, Li L, Zhu X, Gu L, Jiang J, Ren W* (2024). Simultaneous reconstruction of 3D fluorescence distribution and object surface using structured light illumination and dual-camera detection. Optics Express, 32(9).

15. Gao S, Zhang J, Hu Y, Wu Y, Li L, Hu Q, Lou X, Zhu X, Jiang J*, Ren W* (2024). Multifunctional Optical Tomography System with High-Fidelity Surface Extraction Based on a Single Programmable Scanner and Unified Pinhole Modeling. IEEE Transactions on Biomedical Engineering, 71(4), 1391–1403.

16. Zhu X, Gu L, Li R, Chen L, Chen J, Zhou N*, Ren W* (2024). MiniMounter: a low-cost miniaturized microscopy development toolkit for image quality control and enhancement. Journal of Biophotonics, 17(2), e202300214.

17. Ren W*, Dean-Ben XL, Skachokova Z, Augath M, Ni R, Chen Z, Razansky D* (2023). Monitoring mouse brain perfusion with hybrid magnetic resonance optoacoustic tomography. Biomedical Optics Express, 14, 1192–1204.

18. Ren W*, Li L, Zhang J, Vaas M, Klohs J, Ripoll J, Wolf M, Ni R, Rudin M (2022). Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography. Biomedical Optics Express, 13, 3809–3822.

19. Ren W*, Ji B, Guan Y, Cao L, Ni R* (2022). Recent Technical Advances in Accelerating the Clinical Translation of Small Animal Brain Imaging: Hybrid Imaging, Deep Learning, and Transcriptomics. Frontiers in Medicine, 9, 771982.

20. Hu Y, Lafci B, Luzgin A, Wang H, Klohs J, Dean-Ben XL, Ni R, Razansky D*, Ren W* (2022). Deep learning facilitates fully automated brain image registration of optoacoustic tomography and magnetic resonance imaging. Biomedical Optics Express, 13, 4817–4833.

21. Chen Z, Gezginer I, Augath MA, Ren W, Liu YH, Ni R, Dean-Ben XL, Razansky D* (2022). Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging. Light: Science & Applications, 11, 332.

22. Zhou R, Ji B, Kong Y, Qin L, Ren W, Guan Y, Ni R* (2021). PET Imaging of Neuroinflammation in Alzheimer’s Disease. Frontiers in Immunology, 12, 739130.

23. Ren W, Dean-Ben XL, Augath MA, Razansky D* (2021). Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study. Journal of Biophotonics, 14, e202000293.

24. Ren W, Cui S, Alini M, Grad S, Zhou Q, Li Z, Razansky D* (2021). Noninvasive multimodal fluorescence and magnetic resonance imaging of whole-organ intervertebral discs. Biomedical Optics Express, 12, 3214–3227.

--加入上海科技大学前--

25. Ren W*, Jiang J, Costanzo Mata AD, Kalyanov A, Ripoll J, Lindner S, Charbon E, Zhang C, Rudin M, Wolf M (2020). Multimodal imaging combining time-domain near-infrared optical tomography and continuous-wave fluorescence molecular tomography. Optics Express, 28, 9860–9874.

26. Ren W, Isler H, Wolf M, Ripoll J, Rudin M* (2020). Smart Toolkit for Fluorescence Tomography: Simulation, Reconstruction, and Validation. IEEE Transactions on Biomedical Engineering, 67, 16–26.

27. Liu Y, Ren W*, Ammari H (2020). Robust reconstruction of fluorescence molecular tomography with an optimized illumination pattern. Inverse Problems & Imaging, 14, 535–568.

28. Ren W, Skulason H, Schlegel F, Rudin M, Klohs J, Ni R* (2019). Automated registration of magnetic resonance imaging and optoacoustic tomography data for experimental studies. Neurophotonics, 6, 025001.

29. Ni R, Vaas M, Ren W, Klohs J* (2018). Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral optoacoustic tomography. Neurophotonics, 5, 015005.

30. Ren W, Elmer A, Buehlmann D, Augath M-A, Vats D, Ripoll J, Rudin M* (2016). Dynamic Measurement of Tumor Vascular Permeability and Perfusion using a Hybrid System for Simultaneous Magnetic Resonance and Fluorescence Imaging. Molecular Imaging and Biology, 18, 191–200.

书籍章节

1. Ren W*, Ni R* (2024). Noninvasive Visualization of Amyloid-Beta Deposits in Alzheimer’s Amyloidosis Mice via Fluorescence Molecular Tomography Using Contrast Agent. In Biomarkers for Alzheimer’s Disease Drug Development, Chapter 16, pp. 271–285, Springer.

代表性会议论文

1. Gu L, Zhu X, Li R, Zhou N, Ren W* (2025). High resolution miniaturized fluorescence microscopy via Zernike-based spatially-varying deconvolution. European Conference on Biomedical Optics, W1C.3, Optica.

2. Liu Z, Chen R, Tong S, Zhu Z, Gu W, Ren W, Liu J, Zhou Y (2024). Input function separation in dual-tracer 18F-FDG and 68Ga-FAPI-04 single dynamic PET using a recurrent neural network. Society of Nuclear Medicine.

3. Ding H, Cao T, Ren W, Zhang X (2024). HL-SfM: A marker-free and automated hologram registration and tracking framework for image-guided surgery. ICVRV 2024, 166–171.

4. Li L, Shen S, Gao S, Wang Y, Gu L, Li S, Zhu X, Jiang J, Yu J, Ren W* (2023). A self-supervised learning approach for high-resolution diffuse optical tomography using neural fields. BPC 2023, Proc. SPIE.

5. Wu Y, Gao S, Li L, Zhang J, Hu Q, Lou X, Zhu X, Jiang J, Ren W* (2023). Multifunctional optical tomography system combining surface extraction and 3D fluorescence reconstruction. BPC 2023, Proc. SPIE.

6. Zhu X, Gu L, Li R, Chen L, Chen J, Zhou N, Ren W* (2023). Multi-functional accessory toolkit for Miniscope prototyping and image enhancement. BPC 2023, Proc. SPIE.

7. Ren W, Dean-Ben XL, Augath M, Razansky D* (2021). Feasibility study on concurrent optoacoustic tomography and magnetic resonance imaging. Proc. SPIE. [Oral; Best Paper Nomination, Photonics West, top 5%]

8. Ren W*, Jiang J, Di Costanzo MA, Kalyanov A, Ripoll J, Lindner S, Charbon E, Zhang C, Rudin M, Wolf M (2020). Time-domain near-infrared optical tomography guided fluorescence molecular tomography. Biophotonics Congress: Biomedical Optics, OSA.

专利与成果转化

创新创业与技术转化

 •光学仿体服务（2025–至今）：聚焦生物光子学标准仿体及光学系统标定/标准化，相关仿体已被国内主要 fNIRS 厂商采用。

 •KaleiBox 项目负责人（2018–2020）：便携式多功能荧光断层成像系统，获 SNSF BRIDGE 与 Venture Kick 支持，原型机于 2019 年德国汉诺威工业展瑞士馆展出。

专利

1. Ren W, Rudin M. Method for selecting an illumination pattern for a fluorescence molecular tomography measurement. PCT/EP2020/051779.

2. Ren W, Zhu X, Chen L. Microscopic device for small-animal imaging. CN118112769A.

3. Ren W, Zhu X, Gu L. Imaging device combining MRI and optics. CN118161144A.

4. Ren W, Wu Y, Hu Y. Simultaneous data acquisition for 3D fluorescence visualization and surface extraction. CN116839500A.

5. Ren W, Zhu X, Chen L, Gu L. Calibration tool for miniaturized microscopy. CN116661122A.

6. Ren W, Wu Y, Chen L. Dual-view surface extraction and optical tomography using a single camera. CN116576796A.

7. Ren W, Gao S, Wu Y. Non-contact optical tomography with a continuous-wave source. CN115191947A.

荣誉与奖励

代表性成果图示