组织血氧成像在临床研究中的应用：脑与肌肉微血管功能的定量生物标志物/Tissue Oximetry in Clinical Research: Quantitative Microvascular Biomarkers in Brain & Muscle

演讲者:   Michele Lacerenza PIONIRS PhD, CTO 

随着定量组织血氧测量技术的发展，利用近红外光无创精准识别脑组织与骨骼肌微血管功能障碍，正逐渐成为未来临床诊疗中的重要方向。时域近红外光谱技术（Time-Domain Near Infrared Spectroscopy，TD-NIRS）是一种先进的生物光子学方法，能够以极高的精度和可重复性对组织内的血氧水平进行定量测量，该技术已在先进临床研究中得到应用。在本次讲座中，Michele Lacerenza 博士将介绍最新一代 TD-NIRS 设备在临床与实验室研究中的应用进展。基于其与多家世界顶尖重症监护病房（ICU/NICU）及高校的合作，他将展示一系列“从实验室到临床”的转化研究方案，包括：（1）重症脑血流动力学监测及外周肌肉微血管反应性测试；（2）微血管功能障碍的分型与纵向评估指标的建立；（3）通过改进浅层信号抑制，实现更准确的脑功能激活测量；（4）基于肌肉氧合动力学与恢复过程的运动生理学研究。讲座将重点讨论设备的可用性、质量控制及数据报告规范等关键问题，这对于推动多中心、高影响力的 TD-NIRS 临床研究具有重要意义。此次活动也将为在上海地区启动相关合作研究、开展试点项目提供契机，促进医学诊断与生物医学研究的进一步融合与发展。

The use of quantitative tissue oximetry devices, to accurately and non-invasively identify microvascular impairment in cerebral tissue and skeletal muscle, is expected to play a pivotal role in future clinical practice. Time domain near infrared spectroscopy (TD-NIRS) is an advanced optical technique that facilitates precise, reproducible, and quantitative tissue oxygenation measurements and it is currently employed in cutting-edge clinical research. Dr. Michele Lacerenza will present the latest advancement of TD-NIRS devices for clinical research and laboratory applications. Drawing on collaborations with leading ICUs/NICUs and universities worldwide, Lacerenza will showcase translational protocols for: (1) critical care cerebral hemodynamic monitoring and microvascular reactivity testing on peripheral muscles; (2) microvascular impairment phenotyping and longitudinal endpoints; (3) brain functional activation with improved superficial-layer rejection; and (4) exercise physiology through muscle oxygenation kinetics and recovery dynamics. Emphasis will be placed on device usability, quality assurance, and reporting standards to accelerate high-impact, multicenter TD-NIRS studies, including opportunities to initiate pilot projects and new collaboration in Shanghai fostering advancement in medical diagnosis and biomedical research.

报告人简介:

Michele Lacerenza 博士现任意大利 PIONIRS 公司的首席技术官（CTO）兼联合创始人。他于 2018 年在米兰理工大学（Politecnico di Milano）获得物理工程硕士学位（研究方向为纳米光学与光子学），并于 2022 年获得物理学博士学位，期间的研究重点是面向脑和肌肉血氧成像的高集成光学系统的开发。Lacerenza 博士的工作涵盖时域近红外光谱技术（TD-NIRS）的仪器系统设计、定量组织血氧测量方法，以及从神经生理学到临床监测的多领域转化应用。他共同创立的 PIONIRS 公司是米兰理工大学正式认可的衍生企业，并得到了 Micro Photon Devices公司的大力支持。Micro Photon Devices公司位于意大利博尔扎诺（Bolzano），在单光子探测技术领域具有多年的深厚积累。依托这一坚实的技术背景，PIONIRS 致力于研发并推广新一代 TD-NIRS 设备，推动其在全球范围的临床与科研应用。

Michele Lacerenza is CTO and co-founder of PIONIRS s.r.l. He received an M.Sc. in Physics Engineering (nano-optics and photonics, 2018) and a Ph.D. in Physics (2022) from Politecnico di Milano, where he focused on compact photonic platforms for cerebral and muscle oximetry. His work spans instrumentation design for time-domain NIRS (TD-NIRS), quantitative oximetry methods, and translational applications from neurophysiology to clinical monitoring. Officially acknowledged as spin-off company of Politecnico di Milano and also supported by Micro Photon Devices S.r.l., a company based in Bolzano (Italy) having years of experience in single-photon detection, PIONIRS is committed to deliver to the world the next-generation devices for TD-NIRS.